DNA-PK and the TRF2 iDDR inhibit MRN-initiated resection at leading-end telomeres

Telomeres replicated by leading-strand synthesis lack the 3′ overhang required for telomere protection. Surprisingly, resection of these blunt telomeres is initiated by the telomere-specific 5′ exonuclease Apollo rather than the Mre11–Rad50–Nbs1 (MRN) complex, the nuclease that acts at DNA breaks. W...

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Detalles Bibliográficos
Autores principales: Myler, Logan R., Toia, Beatrice, Vaughan, Cara K., Takai, Kaori, Matei, Andreea M., Wu, Peng, Paull, Tanya T., de Lange, Titia, Lottersberger, Francisca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10497418/
https://www.ncbi.nlm.nih.gov/pubmed/37653239
http://dx.doi.org/10.1038/s41594-023-01072-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10497418/
https://www.ncbi.nlm.nih.gov/pubmed/37653239
http://dx.doi.org/10.1038/s41594-023-01072-x

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