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DNA-PK and the TRF2 iDDR inhibit MRN-initiated resection at leading-end telomeres
Telomeres replicated by leading-strand synthesis lack the 3′ overhang required for telomere protection. Surprisingly, resection of these blunt telomeres is initiated by the telomere-specific 5′ exonuclease Apollo rather than the Mre11–Rad50–Nbs1 (MRN) complex, the nuclease that acts at DNA breaks. W...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group US
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10497418/ https://www.ncbi.nlm.nih.gov/pubmed/37653239 http://dx.doi.org/10.1038/s41594-023-01072-x |