Multidisciplinary studies with mutated HIV-1 capsid proteins reveal structural mechanisms of lattice stabilization

HIV-1 capsid (CA) stability is important for viral replication. E45A and P38A mutations enhance and reduce core stability, thus impairing infectivity. Second-site mutations R132T and T216I rescue infectivity. Capsid lattice stability was studied by solving seven crystal structures (in native backgro...

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Detalles Bibliográficos
Autores principales: Gres, Anna T., Kirby, Karen A., McFadden, William M., Du, Haijuan, Liu, Dandan, Xu, Chaoyi, Bryer, Alexander J., Perilla, Juan R., Shi, Jiong, Aiken, Christopher, Fu, Xiaofeng, Zhang, Peijun, Francis, Ashwanth C., Melikyan, Gregory B., Sarafianos, Stefan G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10497533/
https://www.ncbi.nlm.nih.gov/pubmed/37699872
http://dx.doi.org/10.1038/s41467-023-41197-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10497533/
https://www.ncbi.nlm.nih.gov/pubmed/37699872
http://dx.doi.org/10.1038/s41467-023-41197-7

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