The H163A mutation unravels an oxidized conformation of the SARS-CoV-2 main protease

The main protease of SARS-CoV-2 (Mpro) is an important target for developing COVID-19 therapeutics. Recent work has highlighted Mpro’s susceptibility to undergo redox-associated conformational changes in response to cellular and immune-system-induced oxidation. Despite structural evidence indicating...

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Detalles Bibliográficos
Autores principales: Tran, Norman, Dasari, Sathish, Barwell, Sarah A. E., McLeod, Matthew J., Kalyaanamoorthy, Subha, Holyoak, Todd, Ganesan, Aravindhan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10497556/
https://www.ncbi.nlm.nih.gov/pubmed/37699927
http://dx.doi.org/10.1038/s41467-023-40023-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10497556/
https://www.ncbi.nlm.nih.gov/pubmed/37699927
http://dx.doi.org/10.1038/s41467-023-40023-4

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