SHIELD: a platform for high-throughput screening of barrier-type DNA elements in human cells

Chromatin boundary elements contribute to the partitioning of mammalian genomes into topological domains to regulate gene expression. Certain boundary elements are adopted as DNA insulators for safe and stable transgene expression in mammalian cells. These elements, however, are ill-defined and less...

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Detalles Bibliográficos
Autores principales: Zhang, Meng, Ehmann, Mary Elisabeth, Matukumalli, Srija, Boob, Aashutosh Girish, Gilbert, David M., Zhao, Huimin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10497619/
https://www.ncbi.nlm.nih.gov/pubmed/37699958
http://dx.doi.org/10.1038/s41467-023-41468-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10497619/
https://www.ncbi.nlm.nih.gov/pubmed/37699958
http://dx.doi.org/10.1038/s41467-023-41468-3

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