Metformin-induced activation of Ca(2+) signaling prevents immune infiltration/pathology in Sjogren’s syndrome-prone mouse models

Immune cell infiltration and glandular dysfunction are the hallmarks of autoimmune diseases such as primary Sjogren’s syndrome (pSS), however, the mechanism(s) is unknown. Our data show that metformin-treatment induces Ca2+ signaling that restores saliva secretion and prevents immune cell infiltrati...

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Detalles Bibliográficos
Autores principales: Nascimento Da Conceicao, Viviane, Sun, Yuyang, Chai, Xiufang, Ambrus, Julian L., Mishra, Bibhuti B., Singh, Brij B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Research paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10497794/
https://www.ncbi.nlm.nih.gov/pubmed/37711153
http://dx.doi.org/10.1016/j.jtauto.2023.100210

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10497794/
https://www.ncbi.nlm.nih.gov/pubmed/37711153
http://dx.doi.org/10.1016/j.jtauto.2023.100210

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