Cargando…
Metformin-induced activation of Ca(2+) signaling prevents immune infiltration/pathology in Sjogren’s syndrome-prone mouse models
Immune cell infiltration and glandular dysfunction are the hallmarks of autoimmune diseases such as primary Sjogren’s syndrome (pSS), however, the mechanism(s) is unknown. Our data show that metformin-treatment induces Ca2+ signaling that restores saliva secretion and prevents immune cell infiltrati...
| Autores principales: | , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2023
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10497794/ https://www.ncbi.nlm.nih.gov/pubmed/37711153 http://dx.doi.org/10.1016/j.jtauto.2023.100210 |