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Alterations of SIRT1/SIRT3 subcellular distribution in aging undermine cardiometabolic homeostasis during ischemia and reperfusion

Age‐related sensors Sirtuin1 (SIRT1) and Sirtuin3 (SIRT3) play an essential role in the protective response upon myocardial ischemia and/or reperfusion (I/R). However, the subcellular localization and co‐regulatory network between cardiac SIRT1 and SIRT3 remain unknown, especially their effects on a...

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Detalles Bibliográficos
Autores principales: Zhang, Jingwen, Wang, Hao, Slotabec, Lily, Cheng, Feng, Tan, Yi, Li, Ji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10497814/
https://www.ncbi.nlm.nih.gov/pubmed/37537789
http://dx.doi.org/10.1111/acel.13930