ApoE4 exacerbates the senescence of hippocampal neurons and spatial cognitive impairment by downregulating acetyl‐CoA level

Although aging and apolipoprotein E (APOE) ε4 allele have been documented as two major risk factors for late‐onset Alzheimer's disease (LOAD), their interaction and potential underlying mechanisms remain unelucidated. Using humanized ApoE4‐ and ApoE3‐ target replacement mice, we found the accum...

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Detalles Bibliográficos
Autores principales: Lv, Shuixin, Zhang, Yusi, Lin, Yingbin, Fang, Wenting, Wang, Yu, Li, Zihang, Lin, Anlan, Dai, Xiaoman, Ye, Qinyong, Zhang, Jing, Chen, Xiaochun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10497817/
https://www.ncbi.nlm.nih.gov/pubmed/37594184
http://dx.doi.org/10.1111/acel.13932

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10497817/
https://www.ncbi.nlm.nih.gov/pubmed/37594184
http://dx.doi.org/10.1111/acel.13932

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