Identification of new drugs to counteract anti-spike IgG-induced hyperinflammation in severe COVID-19

Previously, we and others have shown that SARS-CoV-2 spike-specific IgG antibodies play a major role in disease severity in COVID-19 by triggering macrophage hyperactivation, disrupting endothelial barrier integrity, and inducing thrombus formation. This hyperinflammation is dependent on high levels...

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Detalles Bibliográficos
Autores principales: Geyer, Chiara E, Chen, Hung-Jen, Bye, Alexander P, Manz, Xue D, Guerra, Denise, Caniels, Tom G, Bijl, Tom PL, Griffith, Guillermo R, Hoepel, Willianne, de Taeye, Steven W, Veth, Jennifer, Vlaar, Alexander PJ, Vidarsson, Gestur, Bogaard, Harm Jan, Aman, Jurjan, Gibbins, Jonathan M, van Gils, Marit J, de Winther, Menno PJ, den Dunnen, Jeroen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10497933/
https://www.ncbi.nlm.nih.gov/pubmed/37699657
http://dx.doi.org/10.26508/lsa.202302106

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10497933/
https://www.ncbi.nlm.nih.gov/pubmed/37699657
http://dx.doi.org/10.26508/lsa.202302106

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