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Identification of new drugs to counteract anti-spike IgG-induced hyperinflammation in severe COVID-19
Previously, we and others have shown that SARS-CoV-2 spike-specific IgG antibodies play a major role in disease severity in COVID-19 by triggering macrophage hyperactivation, disrupting endothelial barrier integrity, and inducing thrombus formation. This hyperinflammation is dependent on high levels...
Autores principales: | Geyer, Chiara E, Chen, Hung-Jen, Bye, Alexander P, Manz, Xue D, Guerra, Denise, Caniels, Tom G, Bijl, Tom PL, Griffith, Guillermo R, Hoepel, Willianne, de Taeye, Steven W, Veth, Jennifer, Vlaar, Alexander PJ, Vidarsson, Gestur, Bogaard, Harm Jan, Aman, Jurjan, Gibbins, Jonathan M, van Gils, Marit J, de Winther, Menno PJ, den Dunnen, Jeroen |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Life Science Alliance LLC
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10497933/ https://www.ncbi.nlm.nih.gov/pubmed/37699657 http://dx.doi.org/10.26508/lsa.202302106 |
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