Protons taken hostage: Dynamic H-bond networks of the pH-sensing GPR68

Proton-sensing G Protein Coupled Receptors (GPCRs) sense changes in the extracellular pH to effect cell signaling for cellular homeostasis. They tend to be overexpressed in solid tumors associated with acidic extracellular pH, and are of direct interest as drug targets. How proton-sensing GPCRs sens...

Descripción completa

Detalles Bibliográficos
Autores principales: Kapur, Bhav, Baldessari, Filippo, Lazaratos, Michalis, Nar, Herbert, Schnapp, Gisela, Giorgetti, Alejandro, Bondar, Ana-Nicoleta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10498176/
https://www.ncbi.nlm.nih.gov/pubmed/37711190
http://dx.doi.org/10.1016/j.csbj.2023.08.034

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10498176/
https://www.ncbi.nlm.nih.gov/pubmed/37711190
http://dx.doi.org/10.1016/j.csbj.2023.08.034

Ejemplares similares