Multicomponent reaction (MCR) for constructing bis-spirocyclohexane skeletons using β-nitrostyrene derived MBH acetates, 1,3-indanedione and aldehydes via [1 + 1 + 1 + 3] annulation

An AB(2)C type four-component quadruple cascade reaction has been established between nitroallylic MBH acetate, 1,3-indanedione and aldehyde for generating bis-spirocyclohexanes. This reaction progressed in an unusual [1 + 1 + 1 + 3] annulation manner via a Knoevenagel/Michael/Michael/Michael sequen...

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Detalles Bibliográficos
Autores principales: Gudise, Veera Babu, Anwar, Shaik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10498677/
https://www.ncbi.nlm.nih.gov/pubmed/37711377
http://dx.doi.org/10.1039/d3ra04996e
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author Gudise, Veera Babu
Anwar, Shaik
author_facet Gudise, Veera Babu
Anwar, Shaik
author_sort Gudise, Veera Babu
collection PubMed
description An AB(2)C type four-component quadruple cascade reaction has been established between nitroallylic MBH acetate, 1,3-indanedione and aldehyde for generating bis-spirocyclohexanes. This reaction progressed in an unusual [1 + 1 + 1 + 3] annulation manner via a Knoevenagel/Michael/Michael/Michael sequence, resulting in the generation of three/four chiral centres, and two all-carbon quaternary centres through the formation of 3 new C–C bonds.
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spelling pubmed-104986772023-09-14 Multicomponent reaction (MCR) for constructing bis-spirocyclohexane skeletons using β-nitrostyrene derived MBH acetates, 1,3-indanedione and aldehydes via [1 + 1 + 1 + 3] annulation Gudise, Veera Babu Anwar, Shaik RSC Adv Chemistry An AB(2)C type four-component quadruple cascade reaction has been established between nitroallylic MBH acetate, 1,3-indanedione and aldehyde for generating bis-spirocyclohexanes. This reaction progressed in an unusual [1 + 1 + 1 + 3] annulation manner via a Knoevenagel/Michael/Michael/Michael sequence, resulting in the generation of three/four chiral centres, and two all-carbon quaternary centres through the formation of 3 new C–C bonds. The Royal Society of Chemistry 2023-09-13 /pmc/articles/PMC10498677/ /pubmed/37711377 http://dx.doi.org/10.1039/d3ra04996e Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Gudise, Veera Babu
Anwar, Shaik
Multicomponent reaction (MCR) for constructing bis-spirocyclohexane skeletons using β-nitrostyrene derived MBH acetates, 1,3-indanedione and aldehydes via [1 + 1 + 1 + 3] annulation
title Multicomponent reaction (MCR) for constructing bis-spirocyclohexane skeletons using β-nitrostyrene derived MBH acetates, 1,3-indanedione and aldehydes via [1 + 1 + 1 + 3] annulation
title_full Multicomponent reaction (MCR) for constructing bis-spirocyclohexane skeletons using β-nitrostyrene derived MBH acetates, 1,3-indanedione and aldehydes via [1 + 1 + 1 + 3] annulation
title_fullStr Multicomponent reaction (MCR) for constructing bis-spirocyclohexane skeletons using β-nitrostyrene derived MBH acetates, 1,3-indanedione and aldehydes via [1 + 1 + 1 + 3] annulation
title_full_unstemmed Multicomponent reaction (MCR) for constructing bis-spirocyclohexane skeletons using β-nitrostyrene derived MBH acetates, 1,3-indanedione and aldehydes via [1 + 1 + 1 + 3] annulation
title_short Multicomponent reaction (MCR) for constructing bis-spirocyclohexane skeletons using β-nitrostyrene derived MBH acetates, 1,3-indanedione and aldehydes via [1 + 1 + 1 + 3] annulation
title_sort multicomponent reaction (mcr) for constructing bis-spirocyclohexane skeletons using β-nitrostyrene derived mbh acetates, 1,3-indanedione and aldehydes via [1 + 1 + 1 + 3] annulation
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10498677/
https://www.ncbi.nlm.nih.gov/pubmed/37711377
http://dx.doi.org/10.1039/d3ra04996e
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