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Selection of optimised ligands by fluorescence-activated bead sorting

The chemistry of aptamers is largely limited to natural nucleotides, and although modifications of nucleic acids can enhance target aptamer affinity, there has not yet been a technology for selecting the right modifications in the right locations out of the vast number of possibilities, because enzy...

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Detalles Bibliográficos
Autores principales: Paul, Alexandra R., Falsaperna, Mario, Lavender, Helen, Garrett, Michelle D., Serpell, Christopher J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10498682/
https://www.ncbi.nlm.nih.gov/pubmed/37712023
http://dx.doi.org/10.1039/d3sc03581f