Development of in silico models to predict viscosity and mouse clearance using a comprehensive analytical data set collected on 83 scaffold-consistent monoclonal antibodies

Biologic drug discovery pipelines are designed to deliver protein therapeutics that have exquisite functional potency and selectivity while also manifesting biophysical characteristics suitable for manufacturing, storage, and convenient administration to patients. The ability to use computational me...

Descripción completa

Detalles Bibliográficos
Autores principales: Mock, Marissa, Jacobitz, Alex W., Langmead, Christopher James, Sudom, Athena, Yoo, Daniel, Humphreys, Sara C., Alday, Mai, Alekseychyk, Larysa, Angell, Nicolas, Bi, Vivian, Catterall, Hannah, Chen, Chen-Chun, Chou, Hui-Ting, Conner, Kip P., Cook, Kevin D., Correia, Ana R., Dykstra, Andrew, Ghimire-Rijal, Sudipa, Graham, Kevin, Grandsard, Peter, Huh, Joon, Hui, John O., Jain, Mani, Jann, Victoria, Jia, Lei, Johnstone, Sheree, Khanal, Neelam, Kolvenbach, Carl, Narhi, Linda, Padaki, Rupa, Pelegri-O’Day, Emma M., Qi, Wei, Razinkov, Vladimir, Rice, Austin J., Smith, Richard, Spahr, Christopher, Stevens, Jennitte, Sun, Yax, Thomas, Veena A., van Driesche, Sarah, Vernon, Robert, Wagner, Victoria, Walker, Kenneth W., Wei, Yangjie, Winters, Dwight, Yang, Melissa, Campuzano, Iain D. G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10498806/
https://www.ncbi.nlm.nih.gov/pubmed/37698932
http://dx.doi.org/10.1080/19420862.2023.2256745

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10498806/
https://www.ncbi.nlm.nih.gov/pubmed/37698932
http://dx.doi.org/10.1080/19420862.2023.2256745

Ejemplares similares