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CST–Polα/Primase: the second telomere maintenance machine

It has been known for decades that telomerase extends the 3′ end of linear eukaryotic chromosomes and dictates the telomeric repeat sequence based on the template in its RNA. However, telomerase does not mitigate sequence loss at the 5′ ends of chromosomes, which results from lagging strand DNA synt...

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Detalles Bibliográficos
Autores principales: Cai, Sarah W., de Lange, Titia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10499019/
https://www.ncbi.nlm.nih.gov/pubmed/37495394
http://dx.doi.org/10.1101/gad.350479.123