The dual lipid desaturase/hydroxylase DEGS2 controls phytoceramide levels necessary to counter intestinal inflammation

Intestinal immunity is dependent on barrier function to maintain quiescence. The mechanisms for the maintenance of this barrier are not fully understood. Delta 4-desaturase, sphingolipid 2 (DEGS2) is a lipid desaturase and hydroxylase that catalyzes the synthesis of ceramide and phytoceramide from d...

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Detalles Bibliográficos
Autores principales: Song, Ran, Fond, Aaron, Li, Xiaohong, Tang, Miao, Zhan, Xiaoming, Gordillo, Ruth, Moresco, Eva Marie Y., Beutler, Bruce, Turer, Emre E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10499023/
https://www.ncbi.nlm.nih.gov/pubmed/37589563
http://dx.doi.org/10.1242/dmm.050043

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10499023/
https://www.ncbi.nlm.nih.gov/pubmed/37589563
http://dx.doi.org/10.1242/dmm.050043

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