Competition for calnexin binding regulates secretion and turnover of misfolded GPI-anchored proteins
In mammalian cells, misfolded glycosylphosphatidylinositol (GPI)-anchored proteins (GPI-APs) are cleared out of the ER to the Golgi via a constitutive and a stress-inducible pathway called RESET. From the Golgi, misfolded GPI-APs transiently access the cell surface prior to rapid internalization for...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Rockefeller University Press
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10499038/ https://www.ncbi.nlm.nih.gov/pubmed/37702712 http://dx.doi.org/10.1083/jcb.202108160 |