Characterization of norbelladine synthase and noroxomaritidine/norcraugsodine reductase reveals a novel catalytic route for the biosynthesis of Amaryllidaceae alkaloids including the Alzheimer’s drug galanthamine

Amaryllidaceae alkaloids (AAs) are a large group of plant specialized metabolites with diverse pharmacological properties. Norbelladine is the entry compound in AAs biosynthesis and is produced from the condensation of tyramine and 3,4-dihydroxybenzaldehyde (3,4-DHBA). There are two reported enzymes...

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Detalles Bibliográficos
Autores principales: Majhi, Bharat Bhusan, Gélinas, Sarah-Eve, Mérindol, Natacha, Ricard, Simon, Desgagné-Penix, Isabel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Plant Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10499049/
https://www.ncbi.nlm.nih.gov/pubmed/37711303
http://dx.doi.org/10.3389/fpls.2023.1231809

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10499049/
https://www.ncbi.nlm.nih.gov/pubmed/37711303
http://dx.doi.org/10.3389/fpls.2023.1231809

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