Cargando…

Evaluation of Salivary Interleukin-6 in Patients with Oral Squamous Cell Carcinoma, Oral Potentially Malignant Disorders, Chronic Periodontitis and in Healthy Controls - A Cross-Sectional Comparative Study

INTRODUCTION: Oral squamous cell carcinoma (OSCC) accounts for 95% among all head and neck cancers. Literature reveals saliva as a predictive, diagnostic and prognostic tool in carcinoma, inflammatory and genetic disorders. Expression of salivary interleukin-6 (IL-6) has been reported in patients wi...

Descripción completa

Detalles Bibliográficos
Autores principales: Rani, N. Alice Josephine, Vardhan, B. G. Harsha, Srinivasan, Srividhya, Gopal, Saraswathi K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10499290/
https://www.ncbi.nlm.nih.gov/pubmed/37711518
http://dx.doi.org/10.4103/ams.ams_240_22
_version_ 1785105676891062272
author Rani, N. Alice Josephine
Vardhan, B. G. Harsha
Srinivasan, Srividhya
Gopal, Saraswathi K.
author_facet Rani, N. Alice Josephine
Vardhan, B. G. Harsha
Srinivasan, Srividhya
Gopal, Saraswathi K.
author_sort Rani, N. Alice Josephine
collection PubMed
description INTRODUCTION: Oral squamous cell carcinoma (OSCC) accounts for 95% among all head and neck cancers. Literature reveals saliva as a predictive, diagnostic and prognostic tool in carcinoma, inflammatory and genetic disorders. Expression of salivary interleukin-6 (IL-6) has been reported in patients with OSCC and in oral potentially malignant disorders (OPMDs). This study aims at the following objectives: • To evaluate the changes in the salivary levels of IL-6 in healthy individuals and those with chronic periodontitis (CP), OPMD and OSCC. • To compare the estimated levels of salivary IL-6 individually in healthy individuals and those with CP, OPMD and OSCC. • To assess the estimated levels of salivary IL-6 individually within histopathologically differentiated OSCC. • To analyse salivary IL-6 as a reliable biomarker in the diagnosis of OSCC. MATERIALS AND METHODS: Totally, 60 patients were divided into four groups consisting of 15 patients in each group. Salivary samples were collected by simple drooling method. The concentration of IL-6 is to be determined by using Quantitative sandwich ELISA technique. All analyses were carried out using Statistical Package for Social Sciences (SPSS). RESULTS: The concentration values of IL-6 were found to be more in OSCC group in comparison with the other three groups and the concentration values of OPMD were found to be more than in the CP and control group and was statistically significant. DISCUSSION: We attempted a study to evaluate the salivary IL-6 in patients with OSCC, OPMDs and CP in comparison with the healthy controls. We achieved a pragmatic result showed that salivary IL-6 can be a reliable biomarker in the detection of OSCC. Saliva, due its wide array of functional characteristics, is an upcoming diagnostic fluid in the field of medicine and salivary IL-6 can be one such biomarker in the diagnosis of OSCC.
format Online
Article
Text
id pubmed-10499290
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Wolters Kluwer - Medknow
record_format MEDLINE/PubMed
spelling pubmed-104992902023-09-14 Evaluation of Salivary Interleukin-6 in Patients with Oral Squamous Cell Carcinoma, Oral Potentially Malignant Disorders, Chronic Periodontitis and in Healthy Controls - A Cross-Sectional Comparative Study Rani, N. Alice Josephine Vardhan, B. G. Harsha Srinivasan, Srividhya Gopal, Saraswathi K. Ann Maxillofac Surg Original Article - Comparative Study INTRODUCTION: Oral squamous cell carcinoma (OSCC) accounts for 95% among all head and neck cancers. Literature reveals saliva as a predictive, diagnostic and prognostic tool in carcinoma, inflammatory and genetic disorders. Expression of salivary interleukin-6 (IL-6) has been reported in patients with OSCC and in oral potentially malignant disorders (OPMDs). This study aims at the following objectives: • To evaluate the changes in the salivary levels of IL-6 in healthy individuals and those with chronic periodontitis (CP), OPMD and OSCC. • To compare the estimated levels of salivary IL-6 individually in healthy individuals and those with CP, OPMD and OSCC. • To assess the estimated levels of salivary IL-6 individually within histopathologically differentiated OSCC. • To analyse salivary IL-6 as a reliable biomarker in the diagnosis of OSCC. MATERIALS AND METHODS: Totally, 60 patients were divided into four groups consisting of 15 patients in each group. Salivary samples were collected by simple drooling method. The concentration of IL-6 is to be determined by using Quantitative sandwich ELISA technique. All analyses were carried out using Statistical Package for Social Sciences (SPSS). RESULTS: The concentration values of IL-6 were found to be more in OSCC group in comparison with the other three groups and the concentration values of OPMD were found to be more than in the CP and control group and was statistically significant. DISCUSSION: We attempted a study to evaluate the salivary IL-6 in patients with OSCC, OPMDs and CP in comparison with the healthy controls. We achieved a pragmatic result showed that salivary IL-6 can be a reliable biomarker in the detection of OSCC. Saliva, due its wide array of functional characteristics, is an upcoming diagnostic fluid in the field of medicine and salivary IL-6 can be one such biomarker in the diagnosis of OSCC. Wolters Kluwer - Medknow 2023 2023-07-26 /pmc/articles/PMC10499290/ /pubmed/37711518 http://dx.doi.org/10.4103/ams.ams_240_22 Text en Copyright: © 2023 Annals of Maxillofacial Surgery https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article - Comparative Study
Rani, N. Alice Josephine
Vardhan, B. G. Harsha
Srinivasan, Srividhya
Gopal, Saraswathi K.
Evaluation of Salivary Interleukin-6 in Patients with Oral Squamous Cell Carcinoma, Oral Potentially Malignant Disorders, Chronic Periodontitis and in Healthy Controls - A Cross-Sectional Comparative Study
title Evaluation of Salivary Interleukin-6 in Patients with Oral Squamous Cell Carcinoma, Oral Potentially Malignant Disorders, Chronic Periodontitis and in Healthy Controls - A Cross-Sectional Comparative Study
title_full Evaluation of Salivary Interleukin-6 in Patients with Oral Squamous Cell Carcinoma, Oral Potentially Malignant Disorders, Chronic Periodontitis and in Healthy Controls - A Cross-Sectional Comparative Study
title_fullStr Evaluation of Salivary Interleukin-6 in Patients with Oral Squamous Cell Carcinoma, Oral Potentially Malignant Disorders, Chronic Periodontitis and in Healthy Controls - A Cross-Sectional Comparative Study
title_full_unstemmed Evaluation of Salivary Interleukin-6 in Patients with Oral Squamous Cell Carcinoma, Oral Potentially Malignant Disorders, Chronic Periodontitis and in Healthy Controls - A Cross-Sectional Comparative Study
title_short Evaluation of Salivary Interleukin-6 in Patients with Oral Squamous Cell Carcinoma, Oral Potentially Malignant Disorders, Chronic Periodontitis and in Healthy Controls - A Cross-Sectional Comparative Study
title_sort evaluation of salivary interleukin-6 in patients with oral squamous cell carcinoma, oral potentially malignant disorders, chronic periodontitis and in healthy controls - a cross-sectional comparative study
topic Original Article - Comparative Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10499290/
https://www.ncbi.nlm.nih.gov/pubmed/37711518
http://dx.doi.org/10.4103/ams.ams_240_22
work_keys_str_mv AT raninalicejosephine evaluationofsalivaryinterleukin6inpatientswithoralsquamouscellcarcinomaoralpotentiallymalignantdisorderschronicperiodontitisandinhealthycontrolsacrosssectionalcomparativestudy
AT vardhanbgharsha evaluationofsalivaryinterleukin6inpatientswithoralsquamouscellcarcinomaoralpotentiallymalignantdisorderschronicperiodontitisandinhealthycontrolsacrosssectionalcomparativestudy
AT srinivasansrividhya evaluationofsalivaryinterleukin6inpatientswithoralsquamouscellcarcinomaoralpotentiallymalignantdisorderschronicperiodontitisandinhealthycontrolsacrosssectionalcomparativestudy
AT gopalsaraswathik evaluationofsalivaryinterleukin6inpatientswithoralsquamouscellcarcinomaoralpotentiallymalignantdisorderschronicperiodontitisandinhealthycontrolsacrosssectionalcomparativestudy