Divergent regulation of KCNQ1/E1 by targeted recruitment of protein kinase A to distinct sites on the channel complex

The slow delayed rectifier potassium current, I(Ks), conducted through pore-forming Q1 and auxiliary E1 ion channel complexes is important for human cardiac action potential repolarization. During exercise or fright, I(Ks) is up-regulated by protein kinase A (PKA)-mediated Q1 phosphorylation to main...

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Detalles Bibliográficos
Autores principales: Zou, Xinle, Shanmugam, Sri Karthika, Kanner, Scott A, Sampson, Kevin J, Kass, Robert S, Colecraft, Henry M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10499372/
https://www.ncbi.nlm.nih.gov/pubmed/37650513
http://dx.doi.org/10.7554/eLife.83466

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10499372/
https://www.ncbi.nlm.nih.gov/pubmed/37650513
http://dx.doi.org/10.7554/eLife.83466

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