Endothelial activation and fibrotic changes are impeded by laminar flow-induced CHK1-SENP2 activity through mechanisms distinct from endothelial-to-mesenchymal cell transition

BACKGROUND: The deSUMOylase sentrin-specific isopeptidase 2 (SENP2) plays a crucial role in atheroprotection. However, the phosphorylation of SENP2 at T368 under disturbed flow (D-flow) conditions hinders its nuclear function and promotes endothelial cell (EC) activation. SUMOylation has been implic...

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Detalles Bibliográficos
Autores principales: Nguyen, Minh T. H., Imanishi, Masaki, Li, Shengyu, Chau, Khanh, Banerjee, Priyanka, Velatooru, Loka reddy, Ko, Kyung Ae, Samanthapudi, Venkata S. K., Gi, Young J., Lee, Ling-Ling, Abe, Rei J., McBeath, Elena, Deswal, Anita, Lin, Steven H., Palaskas, Nicolas L., Dantzer, Robert, Fujiwara, Keigi, Borchrdt, Mae K., Turcios, Estefani Berrios, Olmsted-Davis, Elizabeth A., Kotla, Sivareddy, Cooke, John P., Wang, Guangyu, Abe, Jun-ichi, Le, Nhat-Tu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Cardiovascular Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10499395/
https://www.ncbi.nlm.nih.gov/pubmed/37711550
http://dx.doi.org/10.3389/fcvm.2023.1187490

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10499395/
https://www.ncbi.nlm.nih.gov/pubmed/37711550
http://dx.doi.org/10.3389/fcvm.2023.1187490

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