Fully human monoclonal antibody targeting activated ADAM10 on colorectal cancer cells

Metastasis and chemoresistance in colorectal cancer are mediated by certain poorly differentiated cancer cells, known as cancer stem cells, that are maintained by Notch downstream signaling initiated upon Notch cleavage by the metalloprotease ADAM10. It has been shown that ADAM10 overexpression corr...

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Detalles Bibliográficos
Autores principales: Saha, Nayanendu, Baek, Du-San, Mendoza, Rachelle P., Robev, Dorothea, Xu, Yan, Goldgur, Yehuda, De La Cruz, M. Jason, de Stanchina, Elisa, Janes, Peter W., Xu, Kai, Dimitrov, Dimiter S., Nikolov, Dimitar B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10499537/
https://www.ncbi.nlm.nih.gov/pubmed/36917886
http://dx.doi.org/10.1016/j.biopha.2023.114494

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10499537/
https://www.ncbi.nlm.nih.gov/pubmed/36917886
http://dx.doi.org/10.1016/j.biopha.2023.114494

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