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Pervasive downstream RNA hairpins dynamically dictate start-codon selection

Translational reprogramming allows organisms to adapt to changing conditions. Upstream start codons (uAUGs), which are prevalently present in mRNAs, have crucial roles in regulating translation by providing alternative translation start sites(1–4). However, what determines this selective initiation...

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Detalles Bibliográficos
Autores principales: Xiang, Yezi, Huang, Wenze, Tan, Lianmei, Chen, Tianyuan, He, Yang, Irving, Patrick S., Weeks, Kevin M., Zhang, Qiangfeng Cliff, Dong, Xinnian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10499604/
https://www.ncbi.nlm.nih.gov/pubmed/37674078
http://dx.doi.org/10.1038/s41586-023-06500-y