The mRNA expression and secretion of granzyme B are up-regulated via the histamine H2 receptor in human CD4(+) T cells

INTRODUCTION: Granzyme B (GZMB), a serine protease with cytotoxic and immunomodulatory functions, shows elevated levels in blood plasma of patients with atopic dermatitis (AD). It has been observed that GZMB expression in CD4(+) and CD8(+) T cells is higher in lesional skin in AD than in healthy ski...

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Detalles Bibliográficos
Autores principales: Dawodu, Damilola, Sand, Sophie, Nikolouli, Eirini, Werfel, Thomas, Mommert, Susanne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Original Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10499701/
https://www.ncbi.nlm.nih.gov/pubmed/37470818
http://dx.doi.org/10.1007/s00011-023-01759-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10499701/
https://www.ncbi.nlm.nih.gov/pubmed/37470818
http://dx.doi.org/10.1007/s00011-023-01759-3

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