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The mRNA expression and secretion of granzyme B are up-regulated via the histamine H2 receptor in human CD4(+) T cells
INTRODUCTION: Granzyme B (GZMB), a serine protease with cytotoxic and immunomodulatory functions, shows elevated levels in blood plasma of patients with atopic dermatitis (AD). It has been observed that GZMB expression in CD4(+) and CD8(+) T cells is higher in lesional skin in AD than in healthy ski...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Springer International Publishing
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10499701/ https://www.ncbi.nlm.nih.gov/pubmed/37470818 http://dx.doi.org/10.1007/s00011-023-01759-3 |