Cell microparticles loaded with tumor antigen and resiquimod reprogram tumor-associated macrophages and promote stem-like CD8(+) T cells to boost anti-PD-1 therapy

The durable response rate to immune checkpoint blockade such as anti-programmed cell death-1 (PD-1) antibody remains relatively low in hepatocellular carcinoma (HCC), mainly depending on an immunosuppressive microenvironment with limited number of CD8(+) T cells, especially stem-like CD8(+) T cells,...

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Detalles Bibliográficos
Autores principales: Zhang, Xiaoqiong, Wei, Zhaohan, Yong, Tuying, Li, Shiyu, Bie, Nana, Li, Jianye, Li, Xin, Liu, Haojie, Xu, Hang, Yan, Yuchen, Zhang, Bixiang, Chen, Xiaoping, Yang, Xiangliang, Gan, Lu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10499806/
https://www.ncbi.nlm.nih.gov/pubmed/37704614
http://dx.doi.org/10.1038/s41467-023-41438-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10499806/
https://www.ncbi.nlm.nih.gov/pubmed/37704614
http://dx.doi.org/10.1038/s41467-023-41438-9

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