Gut barrier defects, intestinal immune hyperactivation and enhanced lipid catabolism drive lethality in NGLY1-deficient Drosophila

Intestinal barrier dysfunction leads to inflammation and associated metabolic changes. However, the relative impact of gut bacteria versus non-bacterial insults on animal health in the context of barrier dysfunction is not well understood. Here, we establish that loss of Drosophila N-glycanase 1 (Pn...

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Detalles Bibliográficos
Autores principales: Pandey, Ashutosh, Galeone, Antonio, Han, Seung Yeop, Story, Benjamin A., Consonni, Gaia, Mueller, William F., Steinmetz, Lars M., Vaccari, Thomas, Jafar-Nejad, Hamed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10499810/
https://www.ncbi.nlm.nih.gov/pubmed/37704604
http://dx.doi.org/10.1038/s41467-023-40910-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10499810/
https://www.ncbi.nlm.nih.gov/pubmed/37704604
http://dx.doi.org/10.1038/s41467-023-40910-w

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