Cargando…

CSF proteome profiling reveals biomarkers to discriminate dementia with Lewy bodies from Alzheimer´s disease

Diagnosis of dementia with Lewy bodies (DLB) is challenging and specific biofluid biomarkers are highly needed. We employed proximity extension-based assays to measure 665 proteins in the cerebrospinal fluid (CSF) from patients with DLB (n = 109), Alzheimer´s disease (AD, n = 235) and cognitively un...

Descripción completa

Detalles Bibliográficos
Autores principales:	del Campo, Marta, Vermunt, Lisa, Peeters, Carel F. W., Sieben, Anne, Hok-A-Hin, Yanaika S., Lleó, Alberto, Alcolea, Daniel, van Nee, Mirrelijn, Engelborghs, Sebastiaan, van Alphen, Juliette L., Arezoumandan, Sanaz, Chen-Plotkin, Alice, Irwin, David J., van der Flier, Wiesje M., Lemstra, Afina W., Teunissen, Charlotte E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10499811/ https://www.ncbi.nlm.nih.gov/pubmed/37704597 http://dx.doi.org/10.1038/s41467-023-41122-y

Ejemplares similares

Thimet oligopeptidase as a potential CSF biomarker for Alzheimer's disease: A cross‐platform validation study
por: Hok‐A‐Hin, Yanaika S., et al.
Publicado: (2023)

Amyloid-β peptides in cerebrospinal fluid of patients with dementia with Lewy bodies
por: van Steenoven, Inger, et al.
Publicado: (2019)

Neuroinflammatory CSF biomarkers MIF, sTREM1, and sTREM2 show dynamic expression profiles in Alzheimer’s disease
por: Hok-A-Hin, Yanaika S., et al.
Publicado: (2023)

Prodromal Dementia With Lewy Bodies: Clinical Characterization and Predictors of Progression
por: van de Beek, Marleen, et al.
Publicado: (2020)

Disease progression in dementia with Lewy bodies: A longitudinal study on clinical symptoms, quality of life and functional impairment
por: van de Beek, Marleen, et al.
Publicado: (2022)

VGF Peptides in Cerebrospinal Fluid of Patients with Dementia with Lewy Bodies
por: van Steenoven, Inger, et al.
Publicado: (2019)

Contactin-1 Is Reduced in Cerebrospinal Fluid of Parkinson’s Disease Patients and Is Present within Lewy Bodies
por: Chatterjee, Madhurima, et al.
Publicado: (2020)

α‐Synuclein species as potential cerebrospinal fluid biomarkers for dementia with lewy bodies
por: van Steenoven, Inger, et al.
Publicado: (2018)

CSF proteomics in autosomal dominant Alzheimer’s disease highlights parallels with sporadic disease
por: van der Ende, Emma L, et al.
Publicado: (2023)

Genetics Contributes to Concomitant Pathology and Clinical Presentation in Dementia with Lewy Bodies
por: van der Lee, Sven J., et al.
Publicado: (2021)

Diagnostic Value of the CSF α-Synuclein Real-Time Quaking-Induced Conversion Assay at the Prodromal MCI Stage of Dementia With Lewy Bodies
por: Rossi, Marcello, et al.
Publicado: (2021)

Optimizing cCOG, a Web‐based tool, to detect dementia with Lewy Bodies
por: van Gils, Aniek M., et al.
Publicado: (2022)

Trajectories and Determinants of Quality of Life in Dementia with Lewy Bodies and Alzheimer’s Disease
por: van de Beek, Marleen, et al.
Publicado: (2019)

Sex-specific associations with cerebrospinal fluid biomarkers in dementia with Lewy bodies
por: van de Beek, M., et al.
Publicado: (2020)

YKL-40 changes are not detected in post-mortem brain of patients with Alzheimer’s disease and frontotemporal lobar degeneration
por: Hok-A-Hin, Yanaika S., et al.
Publicado: (2022)

EEG Characteristics of Dementia With Lewy Bodies, Alzheimer’s Disease and Mixed Pathology
por: van der Zande, Jessica J., et al.
Publicado: (2018)

Disease-related determinants are associated with mortality in dementia due to Alzheimer’s disease
por: Rhodius-Meester, Hanneke F. M., et al.
Publicado: (2018)

Identification of novel cerebrospinal fluid biomarker candidates for dementia with Lewy bodies: a proteomic approach
por: van Steenoven, Inger, et al.
Publicado: (2020)

Random forest to differentiate dementia with Lewy bodies from Alzheimer's disease
por: Dauwan, Meenakshi, et al.
Publicado: (2016)

Plasma GFAP associates with secondary Alzheimer's pathology in Lewy body disease
por: Cousins, Katheryn A. Q., et al.
Publicado: (2023)

Family History is Associated with Phenotype in Dementia with Lewy Bodies
por: Vergouw, Leonie J.M., et al.
Publicado: (2020)

Differential diagnostic performance of a panel of plasma biomarkers for different types of dementia
por: Thijssen, Elisabeth H., et al.
Publicado: (2022)

Characterization of symptoms and determinants of disease burden in dementia with Lewy bodies: DEvELOP design and baseline results
por: van de Beek, M., et al.
Publicado: (2021)

MRI data-driven clustering reveals different subtypes of Dementia with Lewy bodies
por: Inguanzo, Anna, et al.
Publicado: (2023)

Performance of a [(18)F]Flortaucipir PET Visual Read Method Across the Alzheimer Disease Continuum and in Dementia With Lewy Bodies
por: Coomans, Emma M., et al.
Publicado: (2023)

Determinants of informal care time, distress, depression, and quality of life in care partners along the trajectory of Alzheimer's disease
por: Mank, Arenda, et al.
Publicado: (2023)

Lower (123)I-FP-CIT binding to the striatal dopamine transporter, but not to the extrastriatal serotonin transporter, in Parkinson's disease compared with dementia with Lewy bodies
por: Joling, Merijn, et al.
Publicado: (2018)

Age‐ and disease‐specific reference values for neurofilament light presented in an online interactive support interface
por: Vermunt, Lisa, et al.
Publicado: (2022)

Orthostatic Hypotension: An Important Risk Factor for Clinical Progression to Mild Cognitive Impairment or Dementia. The Amsterdam Dementia Cohort
por: Kleipool, Emma E.F., et al.
Publicado: (2019)

The monoaminergic footprint of depression and psychosis in dementia with Lewy bodies compared to Alzheimer’s disease
por: Vermeiren, Yannick, et al.
Publicado: (2015)

Survival in memory clinic cohort is short, even in young-onset dementia
por: Rhodius-Meester, Hanneke Frederica Maria, et al.
Publicado: (2019)

Fast Marginal Likelihood Estimation of Penalties for Group-Adaptive Elastic Net
por: van Nee, Mirrelijn M., et al.
Publicado: (2022)

Flexible co‐data learning for high‐dimensional prediction
por: van Nee, Mirrelijn M., et al.
Publicado: (2021)

ecpc: an R-package for generic co-data models for high-dimensional prediction
por: van Nee, Mirrelijn M., et al.
Publicado: (2023)

Cerebrospinal fluid and serum MHPG improve Alzheimer's disease versus dementia with Lewy bodies differential diagnosis
por: Janssens, Jana, et al.
Publicado: (2018)

Pre‐amyloid stage of Alzheimer's disease in cognitively normal individuals
por: Tijms, Betty M., et al.
Publicado: (2018)

Contribution of rare homozygous and compound heterozygous VPS13C missense mutations to dementia with Lewy bodies and Parkinson’s disease
por: Smolders, Stefanie, et al.
Publicado: (2021)

Striatal DAT and extrastriatal SERT binding in early-stage Parkinson's disease and dementia with Lewy bodies, compared with healthy controls: An (123)I-FP-CIT SPECT study
por: Joling, Merijn, et al.
Publicado: (2019)

The natural history of primary progressive aphasia: beyond aphasia
por: Ulugut, Hulya, et al.
Publicado: (2021)

Effect of long-term storage in biobanks on cerebrospinal fluid biomarker Aβ(1-42), T-tau, and P-tau values
por: Willemse, Eline A.J., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_nef7shlatt7ag7hvugj5jcesbv