The fructose-bisphosphate, Aldolase A (ALDOA), facilitates DNA-PKcs and ATM kinase activity to regulate DNA double-strand break repair

Glucose metabolism and DNA repair are fundamental cellular processes frequently dysregulated in cancer. In this study, we define a direct role for the glycolytic Aldolase A (ALDOA) protein in DNA double-strand break (DSB) repair. ALDOA is a fructose biphosphate Aldolase that catalyses fructose-1,6-b...

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Detalles Bibliográficos
Autores principales: Sobanski, Thais, Suraweera, Amila, Burgess, Joshua T., Richard, Iain, Cheong, Chee Man, Dave, Keyur, Rose, Maddison, Adams, Mark N., O’Byrne, Kenneth J., Richard, Derek J., Bolderson, Emma
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10499815/
https://www.ncbi.nlm.nih.gov/pubmed/37704669
http://dx.doi.org/10.1038/s41598-023-41133-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10499815/
https://www.ncbi.nlm.nih.gov/pubmed/37704669
http://dx.doi.org/10.1038/s41598-023-41133-1

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