Cargando…

The fructose-bisphosphate, Aldolase A (ALDOA), facilitates DNA-PKcs and ATM kinase activity to regulate DNA double-strand break repair

Glucose metabolism and DNA repair are fundamental cellular processes frequently dysregulated in cancer. In this study, we define a direct role for the glycolytic Aldolase A (ALDOA) protein in DNA double-strand break (DSB) repair. ALDOA is a fructose biphosphate Aldolase that catalyses fructose-1,6-b...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sobanski, Thais, Suraweera, Amila, Burgess, Joshua T., Richard, Iain, Cheong, Chee Man, Dave, Keyur, Rose, Maddison, Adams, Mark N., O’Byrne, Kenneth J., Richard, Derek J., Bolderson, Emma
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10499815/ https://www.ncbi.nlm.nih.gov/pubmed/37704669 http://dx.doi.org/10.1038/s41598-023-41133-1

Ejemplares similares

Cell Metabolism and DNA Repair Pathways: Implications for Cancer Therapy
por: Sobanski, Thais, et al.
Publicado: (2021)

Barrier-to-autointegration-factor (Banf1) modulates DNA double-strand break repair pathway choice via regulation of DNA-dependent kinase (DNA-PK) activity
por: Burgess, Joshua T, et al.
Publicado: (2021)

Structure of fructose bisphosphate aldolase from Bartonella henselae bound to fructose 1,6-bisphosphate
por: Gardberg, Anna, et al.
Publicado: (2011)

Import of fructose bisphosphate aldolase into the glycosomes of Trypanosoma brucei
Publicado: (1987)

Structure of fructose bisphosphate aldolase from Encephalitozoon cuniculi
por: Gardberg, Anna, et al.
Publicado: (2011)

Structure of Toxoplasma gondii fructose-1,6-bisphosphate aldolase
por: Boucher, Lauren E., et al.
Publicado: (2014)

Evolutionary and functional analysis of fructose bisphosphate aldolase of plant parasitic nematodes
por: Prasad, CVS Siva, et al.
Publicado: (2013)

Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK
por: Zhang, Chen-Song, et al.
Publicado: (2017)

Multifunctional Fructose 1,6-Bisphosphate Aldolase as a Therapeutic Target
por: Pirovich, David B., et al.
Publicado: (2021)

Characterization of Fructose-1,6-Bisphosphate Aldolase 1 of Echinococcus multilocularis
por: He, Xuedong, et al.
Publicado: (2021)

Evolution and Functional Diversification of Fructose Bisphosphate Aldolase Genes in Photosynthetic Marine Diatoms
por: Allen, Andrew E., et al.
Publicado: (2012)

Cloning and Characterization of Fructose-1,6-Bisphosphate Aldolase from Euphausia superba
por: Xia, Jikun, et al.
Publicado: (2022)

Distinct plastid fructose bisphosphate aldolases function in photosynthetic and non-photosynthetic metabolism in Arabidopsis
por: Carrera, Dániel Árpád, et al.
Publicado: (2021)

Structure of a rabbit muscle fructose-1,6-bisphosphate aldolase A dimer variant
por: Sherawat, Manashi, et al.
Publicado: (2008)

Diagnostic value of immunoglobulin G antibodies against Candida enolase and fructose-bisphosphate aldolase for candidemia
por: Li, Fang-qiu, et al.
Publicado: (2013)

Fructose 1,6-Bisphosphate Aldolase, a Novel Immunogenic Surface Protein on Listeria Species
por: Mendonça, Marcelo, et al.
Publicado: (2016)

Network Basis for the Heat-Adapted Structural Thermostability of Bacterial Class II Fructose Bisphosphate Aldolase
por: Wang, Guangyu
Publicado: (2023)

Chemotherapeutic Compounds Targeting the DNA Double-Strand Break Repair Pathways: The Good, the Bad, and the Promising
por: Jekimovs, Christian, et al.
Publicado: (2014)

The metabolic enzyme fructose-1,6-bisphosphate aldolase acts as a transcriptional regulator in pathogenic Francisella
por: Ziveri, Jason, et al.
Publicado: (2017)

Epitope-Based Peptide Vaccine Against Fructose-Bisphosphate Aldolase of Madurella mycetomatis Using Immunoinformatics Approaches
por: Mohammed, Arwa A, et al.
Publicado: (2018)

Crystallographic snapshots of active site metal shift in E. coli fructose 1,6-bisphosphate aldolase
por: Tran, Huyen-Thi, et al.
Publicado: (2016)

Effects of the Chloroplast Fructose-1,6-Bisphosphate Aldolase Gene on Growth and Low-Temperature Tolerance of Tomato
por: Cai, Bingbing, et al.
Publicado: (2022)

Epitope-Based Peptide Vaccine Design against Fructose Bisphosphate Aldolase of Candida glabrata: An Immunoinformatics Approach
por: Elamin Elhasan, Lina Mohamed, et al.
Publicado: (2021)

Protective and Anti-Pathology Effects of Sm Fructose-1,6-Bisphosphate Aldolase-Based DNA Vaccine against Schistosoma mansoni by Changing Route of Injection
por: Saber, Mohamed, et al.
Publicado: (2013)

Structural and Functional Characterization of Methicillin-Resistant Staphylococcus aureus’s Class IIb Fructose 1,6-Bisphosphate Aldolase
por: Capodagli, Glenn C., et al.
Publicado: (2014)

Analysis of Paracoccidioides secreted proteins reveals fructose 1,6-bisphosphate aldolase as a plasminogen-binding protein
por: Chaves, Edilânia Gomes Araújo, et al.
Publicado: (2015)

Design of Epitope-Based Peptide Vaccine against Pseudomonas aeruginosa Fructose Bisphosphate Aldolase Protein Using Immunoinformatics
por: Elhag, Mustafa, et al.
Publicado: (2020)

Development of fructose-1,6-bisphosphate aldolase enzyme peptide mimics as biocatalysts in direct asymmetric aldol reactions
por: Peme, Thabo, et al.
Publicado: (2021)

Molecular characterization and immune efficacy of fructose-1,6-bisphosphate aldolase from Haemaphysalis longicornis (Acari: Ixodidae)
por: Cao, Yuan-Yuan, et al.
Publicado: (2023)

Non-redundant Functions of ATM and DNA-PKcs in Response to DNA Double-Strand Breaks
por: Caron, Pierre, et al.
Publicado: (2015)

Fructose-1,6-bisphosphate aldolase encoded by a core gene of Mycoplasma hyopneumoniae contributes to host cell adhesion
por: Yu, Yanfei, et al.
Publicado: (2018)

Molecular Characterization of Fructose-1,6-bisphosphate Aldolase From Trichinella spiralis and Its Potential in Inducing Immune Protection
por: Yang, Yong, et al.
Publicado: (2019)

The Surface Protein Fructose-1, 6 Bisphosphate Aldolase of Klebsiella pneumoniae Serotype K1: Role of Interaction with Neutrophils
por: Lee, Chen-Hsiang, et al.
Publicado: (2020)

ATR Contributes More Than ATM in Intra-S-Phase Checkpoint Activation after IR, and DNA-PKcs Facilitates Recovery: Evidence for Modular Integration of ATM/ATR/DNA-PKcs Functions
por: Soni, Aashish, et al.
Publicado: (2022)

Targeting DNA-PKcs and ATM with miR-101 Sensitizes Tumors to Radiation
por: Yan, Dan, et al.
Publicado: (2010)

Inactivation of Fructose-1,6-Bisphosphate Aldolase Prevents Optimal Co-catabolism of Glycolytic and Gluconeogenic Carbon Substrates in Mycobacterium tuberculosis
por: Puckett, Susan, et al.
Publicado: (2014)

Fructose‐1,6‐bisphosphate aldolase of Neisseria meningitidis binds human plasminogen via its C‐terminal lysine residue
por: Shams, Fariza, et al.
Publicado: (2016)

ATM, ATR and DNA-PKcs kinases—the lessons from the mouse models: inhibition ≠ deletion
por: Menolfi, Demis, et al.
Publicado: (2020)

ALDOA inhibits cell cycle arrest induced by DNA damage via the ATM-PLK1 pathway in pancreatic cancer cells
por: Chen, Haidi, et al.
Publicado: (2021)

Chlamydia pneumoniae effector chlamydial outer protein N sequesters fructose bisphosphate aldolase A, providing a benefit to bacterial growth
por: Ishida, Kasumi, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_sdk7ll0anigv3q0m8ugf1cu4qh