High-throughput screening of BAM inhibitors in native membrane environment

The outer membrane insertase of Gram-negative bacteria, BAM, is a key target for urgently needed novel antibiotics. Functional reconstitutions of BAM have so far been limited to synthetic membranes and with low throughput capacity for inhibitor screening. Here, we describe a BAM functional assay in...

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Detalles Bibliográficos
Autores principales: Rath, Parthasarathi, Hermann, Adrian, Schaefer, Ramona, Agustoni, Elia, Vonach, Jean-Marie, Siegrist, Martin, Miscenic, Christian, Tschumi, Andreas, Roth, Doris, Bieniossek, Christoph, Hiller, Sebastian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10499997/
https://www.ncbi.nlm.nih.gov/pubmed/37704632
http://dx.doi.org/10.1038/s41467-023-41445-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10499997/
https://www.ncbi.nlm.nih.gov/pubmed/37704632
http://dx.doi.org/10.1038/s41467-023-41445-w

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