De novo design of highly selective miniprotein inhibitors of integrins αvβ6 and αvβ8

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The RGD (Arg-Gly-Asp)-binding integrins αvβ6 and αvβ8 are clinically validated cancer and fibrosis targets of considerable therapeutic importance. Compounds that can discriminate between homologous αvβ6 and αvβ8 and other RGD integrins, stabilize specific conformational states, and have high thermal...

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Detalles Bibliográficos
Autores principales: Roy, Anindya, Shi, Lei, Chang, Ashley, Dong, Xianchi, Fernandez, Andres, Kraft, John C., Li, Jing, Le, Viet Q., Winegar, Rebecca Viazzo, Cherf, Gerald Maxwell, Slocum, Dean, Poulson, P. Daniel, Casper, Garrett E., Vallecillo-Zúniga, Mary L., Valdoz, Jonard Corpuz, Miranda, Marcos C., Bai, Hua, Kipnis, Yakov, Olshefsky, Audrey, Priya, Tanu, Carter, Lauren, Ravichandran, Rashmi, Chow, Cameron M., Johnson, Max R., Cheng, Suna, Smith, McKaela, Overed-Sayer, Catherine, Finch, Donna K., Lowe, David, Bera, Asim K., Matute-Bello, Gustavo, Birkland, Timothy P., DiMaio, Frank, Raghu, Ganesh, Cochran, Jennifer R., Stewart, Lance J., Campbell, Melody G., Van Ry, Pam M., Springer, Timothy, Baker, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10500007/
https://www.ncbi.nlm.nih.gov/pubmed/37704610
http://dx.doi.org/10.1038/s41467-023-41272-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10500007/
https://www.ncbi.nlm.nih.gov/pubmed/37704610
http://dx.doi.org/10.1038/s41467-023-41272-z

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