Innate immune responses yield tissue-specific bottlenecks that scale with pathogen dose

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To cause infection, pathogens must overcome bottlenecks imposed by the host immune system. These bottlenecks restrict the inoculum and largely determine whether pathogen exposure results in disease. Infection bottlenecks therefore quantify the effectiveness of immune barriers. Here, using a model of...

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Detalles Bibliográficos
Autores principales: Hullahalli, Karthik, Dailey, Katherine G., Waldor, Matthew K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10500177/
https://www.ncbi.nlm.nih.gov/pubmed/37669395
http://dx.doi.org/10.1073/pnas.2309151120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10500177/
https://www.ncbi.nlm.nih.gov/pubmed/37669395
http://dx.doi.org/10.1073/pnas.2309151120

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