Novel Lawsone–Quinoxaline Hybrids as New Dual Binding Site Acetylcholinesterase Inhibitors

[Image: see text] A new family of lawsone–quinoxaline hybrids was designed, synthesized, and evaluated as dual binding site cholinesterase inhibitors (ChEIs). In vitro tests revealed that compound 6d was the most potent AChEI (IC(50) = 20 nM) and BChEI (IC(50) = 220 nM). The compound 6d did not show...

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Detalles Bibliográficos
Autores principales: Suwanhom, Paptawan, Nualnoi, Teerapat, Khongkow, Pasarat, Tipmanee, Varomyalin, Lomlim, Luelak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10500570/
https://www.ncbi.nlm.nih.gov/pubmed/37720764
http://dx.doi.org/10.1021/acsomega.3c02683

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10500570/
https://www.ncbi.nlm.nih.gov/pubmed/37720764
http://dx.doi.org/10.1021/acsomega.3c02683

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