SRT2183 and SRT1720, but not Resveratrol, Inhibit Osteoclast Formation and Resorption in the Presence or Absence of Sirt1

BACKGROUND: Osteoclastic bone resorption markedly increases with aging, leading to osteoporosis characterized by weak and fragile bones. Mice exhibit greater bone resorption and poor bone mass when Sirt1 is removed from their osteoclasts. Here we investigated the ex vivo impacts of putative Sirt1 ac...

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Detalles Bibliográficos
Autores principales: Thiyagarajan, Ramkumar, Gonzalez, Maria Rodríguez, Zaw, Catherine, Seldeen, Kenneth Ladd, Hernandez, Mireya, Pang, Manhui, Troen, Bruce Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10500633/
https://www.ncbi.nlm.nih.gov/pubmed/37711761

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10500633/
https://www.ncbi.nlm.nih.gov/pubmed/37711761

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