Overestimated prediction using polygenic prediction derived from summary statistics

BACKGROUND: When polygenic risk score (PRS) is derived from summary statistics, independence between discovery and test sets cannot be monitored. We compared two types of PRS studies derived from raw genetic data (denoted as rPRS) and the summary statistics for IGAP (sPRS). RESULTS: Two variables wi...

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Detalles Bibliográficos
Autores principales: Park, David Keetae, Chen, Mingshen, Kim, Seungsoo, Joo, Yoonjung Yoonie, Loving, Rebekah K., Kim, Hyoung Seop, Cha, Jiook, Yoo, Shinjae, Kim, Jong Hun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10500750/
https://www.ncbi.nlm.nih.gov/pubmed/37710206
http://dx.doi.org/10.1186/s12863-023-01151-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10500750/
https://www.ncbi.nlm.nih.gov/pubmed/37710206
http://dx.doi.org/10.1186/s12863-023-01151-4

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