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Sex-dependent neuronal effects of α-synuclein reveal that GABAergic transmission is neuroprotective of sleep-controlling neurons

BACKGROUND: Sleep disorders (SDs) are a symptom of the prodromal phase of neurodegenerative disorders that are mechanistically linked to the protein α-synuclein (α-syn) including Parkinson’s disease (PD). SDs during the prodromal phase could result from neurodegeneration induced in state-controlling...

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Detalles Bibliográficos
Autores principales: Santos, Altair Brito Dos, Thaneshwaran, Siganya, Ali, Lara Kamal, Leguizamón, César Ramón Romero, Wang, Yang, Kristensen, Morten Pilgaard, Langkilde, Annette E., Kohlmeier, Kristi A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10500827/
https://www.ncbi.nlm.nih.gov/pubmed/37710341
http://dx.doi.org/10.1186/s13578-023-01105-4