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Cholesterol-dependent amyloid β production: space for multifarious interactions between amyloid precursor protein, secretases, and cholesterol

Amyloid β is considered a key player in the development and progression of Alzheimer’s disease (AD). Many studies investigating the effect of statins on lowering cholesterol suggest that there may be a link between cholesterol levels and AD pathology. Since cholesterol is one of the most abundant li...

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Detalles Bibliográficos
Autores principales: Rudajev, Vladimir, Novotny, Jiri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10500844/
https://www.ncbi.nlm.nih.gov/pubmed/37705117
http://dx.doi.org/10.1186/s13578-023-01127-y