Acid sphingomyelinase mediates ferroptosis induced by high glucose via autophagic degradation of GPX4 in type 2 diabetic osteoporosis

BACKGROUND: Ferroptosis has been implicated in the pathological process of type 2 diabetic osteoporosis (T2DOP), although the specific underlying mechanisms remain largely unknown. This study aimed to clarify the role and possible mechanism of acid sphingomyelinase (ASM)-mediated osteoblast ferropto...

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Detalles Bibliográficos
Autores principales: Du, Yun-xia, Zhao, Yan-tao, Sun, Yong-xin, Xu, Ai-hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10500928/
https://www.ncbi.nlm.nih.gov/pubmed/37710183
http://dx.doi.org/10.1186/s10020-023-00724-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10500928/
https://www.ncbi.nlm.nih.gov/pubmed/37710183
http://dx.doi.org/10.1186/s10020-023-00724-4

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