Identifying a predictive relationship between maximal flow rate and viscosity for subcutaneous administration of macromolecules with recombinant human hyaluronidase PH20 in a miniature pig model

Subcutaneous (SC) infusion of large volumes at rapid flow rates has historically been limited by the glycosaminoglycan hyaluronan (HA), which forms a barrier to bulk fluid flow in the SC space. Recombinant human hyaluronidase PH20 (rHuPH20) depolymerizes HA, temporarily eliminating this barrier to r...

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Detalles Bibliográficos
Autores principales: Connor, Robert J., Clift, Renee, Kang, David W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10501162/
https://www.ncbi.nlm.nih.gov/pubmed/37702020
http://dx.doi.org/10.1080/10717544.2023.2252999

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10501162/
https://www.ncbi.nlm.nih.gov/pubmed/37702020
http://dx.doi.org/10.1080/10717544.2023.2252999

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