Cargando…

Identifying a predictive relationship between maximal flow rate and viscosity for subcutaneous administration of macromolecules with recombinant human hyaluronidase PH20 in a miniature pig model

Subcutaneous (SC) infusion of large volumes at rapid flow rates has historically been limited by the glycosaminoglycan hyaluronan (HA), which forms a barrier to bulk fluid flow in the SC space. Recombinant human hyaluronidase PH20 (rHuPH20) depolymerizes HA, temporarily eliminating this barrier to r...

Descripción completa

Detalles Bibliográficos
Autores principales:	Connor, Robert J., Clift, Renee, Kang, David W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2023
Materias:	Review Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10501162/ https://www.ncbi.nlm.nih.gov/pubmed/37702020 http://dx.doi.org/10.1080/10717544.2023.2252999

Ejemplares similares

ENHANZE(®) drug delivery technology: a novel approach to subcutaneous administration using recombinant human hyaluronidase PH20
por: Locke, Kenneth W., et al.
Publicado: (2019)

Subcutaneous Injection Performance in Yucatan Miniature Pigs with and without Human Hyaluronidase and Auto-injector Tolerability in Humans
por: Shi, Galen H., et al.
Publicado: (2021)

Clinical Immunogenicity of rHuPH20, a Hyaluronidase Enabling Subcutaneous Drug Administration
por: Rosengren, Sanna, et al.
Publicado: (2015)

A Preclinical Investigation into the Effects of Aging on Dermal Hyaluronan Properties and Reconstitution Following Recombinant Human Hyaluronidase PH20 Administration
por: Connor, Robert J., et al.
Publicado: (2020)

Phase 1 trials of PEGylated recombinant human hyaluronidase PH20 in patients with advanced solid tumours
por: Infante, Jeffrey R, et al.
Publicado: (2018)

Phase 1 trials of PEGylated recombinant human hyaluronidase PH20 in patients with advanced solid tumours
por: Infante, Jeffrey R, et al.
Publicado: (2018)

Subcutaneous administration of rituximab (MabThera) and trastuzumab (Herceptin) using hyaluronidase
por: Shpilberg, O, et al.
Publicado: (2013)

Active Expression of Human Hyaluronidase PH20 and Characterization of Its Hydrolysis Pattern
por: Pang, Bo, et al.
Publicado: (2022)

Dispersive effects and focused biodistribution of recombinant human hyaluronidase PH20: A locally acting and transiently active permeation enhancer
por: Kang, David W., et al.
Publicado: (2021)

Hyaluronidase facilitated subcutaneous immunoglobulin in primary immunodeficiency
por: Jolles, Stephen
Publicado: (2013)

Chondrocytes, synoviocytes and dermal fibroblasts all express PH-20, a hyaluronidase active at neutral pH
por: El Hajjaji, Hafida, et al.
Publicado: (2005)

A Phase I Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Recombinant Human Hyaluronidase PH20 Administered Intravenously in Healthy Volunteers
por: Printz, Marie A., et al.
Publicado: (2020)

Long-Term Tolerability, Safety, and Efficacy of Recombinant Human Hyaluronidase-Facilitated Subcutaneous Infusion of Human Immunoglobulin for Primary Immunodeficiency
por: Wasserman, Richard L., et al.
Publicado: (2016)

Human Hyaluronidase PH20 Potentiates the Antitumor Activities of Mesothelin-Specific CAR-T Cells Against Gastric Cancer
por: Zhao, Ruocong, et al.
Publicado: (2021)

Delayed Allergic Reaction to Secondary Administrated Epidural Hyaluronidase
por: Park, A Reum, et al.
Publicado: (2015)

Hyaluronidase as an Aid to Administration of Fluid in the Treatment of Dehydration in Infants
por: Boyd, H. W.
Publicado: (1951)

Hyaluronidase Inhibitor-Incorporated Cross-Linked Hyaluronic Acid Hydrogels for Subcutaneous Injection
por: Kim, Min-Hwan, et al.
Publicado: (2021)

Subcutaneous daratumumab and hyaluronidase-fihj in newly diagnosed or relapsed/refractory multiple myeloma
por: Sanchez, Larysa, et al.
Publicado: (2021)

Effects of Body Mass and Age on the Pharmacokinetics of Subcutaneous or Hyaluronidase-facilitated Subcutaneous Immunoglobulin G in Primary Immunodeficiency Diseases
por: Li, Zhaoyang, et al.
Publicado: (2023)

A Miniaturized Archimedean Screw Pump for High-Viscosity Fluid Pumping in Microfluidics
por: Gucluer, Sinan
Publicado: (2023)

A hyaluronidase activity of the sperm plasma membrane protein PH-20 enables sperm to penetrate the cumulus cell layer surrounding the egg
Publicado: (1994)

Toxicity of the recombinant human hyaluronidase ALT-BC4 on embryonic development
por: Lee, Ji Hye, et al.
Publicado: (2021)

PEGylated recombinant human hyaluronidase (PEGPH20) pre-treatment improves intra-tumour distribution and efficacy of paclitaxel in preclinical models
por: Morosi, Lavinia, et al.
Publicado: (2021)

Hyaluronidase and pH Dual-Responsive Nanoparticles for Targeted Breast Cancer Stem Cells
por: Li, Weinan, et al.
Publicado: (2021)

Human immune globulin 10% with recombinant human hyaluronidase in multifocal motor neuropathy
por: Herraets, Ingrid J. T., et al.
Publicado: (2019)

THE INTERACTIONS OF THE NON-SPECIFIC INHIBITOR OF HYALURONIDASE WITH HYALURONIDASE AND PROTEOLYTIC ENZYMES IN VIVO
por: Hadidian, Z., et al.
Publicado: (1955)

Hyaluronidase injection for the treatment of eyelid edema: a retrospective analysis of 20 patients
por: Hilton, Said, et al.
Publicado: (2014)

Comparative Pharmacokinetics and Insulin Action for Three Rapid-Acting Insulin Analogs Injected Subcutaneously With and Without Hyaluronidase
por: Morrow, Linda, et al.
Publicado: (2013)

Hyaluronidases in Human Diseases
por: Kaul, Aditya, et al.
Publicado: (2021)

Overexpression and Enzymatic Assessment of Antigenic Fragments of Hyaluronidase Recombinant Protein From Streptococcus pyogenes
por: Sadoogh Abbasian, Shabnam, et al.
Publicado: (2014)

Vestibular-evoked myogenic potentials in miniature pigs
por: Shi, Xi, et al.
Publicado: (2016)

Effects of Astaxanthin on Miniature Pig Sperm Cryopreservation
por: Lee, Eunjoo, et al.
Publicado: (2018)

Treatment with high-dose recombinant human hyaluronidase-facilitated subcutaneous immune globulins in patients with juvenile dermatomyositis who are intolerant to intravenous immune globulins: a report of 5 cases
por: Speth, Fabian, et al.
Publicado: (2016)

Pharmacokinetics of glucagon after intravenous, intraperitoneal and subcutaneous administration in a pig model
por: Teigen, Ingrid Anna, et al.
Publicado: (2022)

The Adrenal-Hyaluronidase Relationship in Infection
por: Smith, Geo. H., et al.
Publicado: (1951)

THE REACTIVATION OF HEAT-INACTIVATED HYALURONIDASE
por: Emmart, E. W., et al.
Publicado: (1954)

HYALURONIDASES OF BACTERIAL AND ANIMAL ORIGIN
por: Meyer, Karl, et al.
Publicado: (1941)

Involvement of hyaluronidases in colorectal cancer
por: Bouga, Helen, et al.
Publicado: (2010)

Hyaluronidase sensitivity: Our experience
por: Mayor, Rahul, et al.
Publicado: (2016)

Heterologous expression and mutagenesis of recombinant Vespa affinis hyaluronidase protein (rVesA2)
por: Rungsa, Prapenpuksiri, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_mhu83oemauubpphrnq6lr845ng