Cargando…

ORP8 acts as a lipophagy receptor to mediate lipid droplet turnover

Lipophagy, the selective engulfment of lipid droplets (LDs) by autophagosomes for lysosomal degradation, is critical to lipid and energy homeostasis. Here we show that the lipid transfer protein ORP8 is located on LDs and mediates the encapsulation of LDs by autophagosomal membranes. This function o...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pu, Maomao, Zheng, Wenhui, Zhang, Hongtao, Wan, Wei, Peng, Chao, Chen, Xuebo, Liu, Xinchang, Xu, Zizhen, Zhou, Tianhua, Sun, Qiming, Neculai, Dante, Liu, Wei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10501187/ https://www.ncbi.nlm.nih.gov/pubmed/37707322 http://dx.doi.org/10.1093/procel/pwac063

Ejemplares similares

Join the club: ORP8 is a lipophagy receptor
por: Wang, Zheng, et al.
Publicado: (2023)

ORP5 and ORP8 orchestrate lipid droplet biogenesis and maintenance at ER–mitochondria contact sites
por: Guyard, Valentin, et al.
Publicado: (2022)

ORP5 localizes to ER–lipid droplet contacts and regulates the level of PI(4)P on lipid droplets
por: Du, Ximing, et al.
Publicado: (2019)

Spatial distribution of lipid droplets during starvation: Implications for lipophagy
por: Barbosa, Antonio Daniel, et al.
Publicado: (2016)

Lipid droplet size directs lipolysis and lipophagy catabolism in hepatocytes
por: Schott, Micah B., et al.
Publicado: (2019)

SB2301-mediated perturbation of membrane composition in lipid droplets induces lipophagy and lipid droplets ubiquitination
por: Jung, Jinjoo, et al.
Publicado: (2023)

Hepatic lipophagy: New insights into autophagic catabolism of lipid droplets in the liver
por: Schulze, Ryan J., et al.
Publicado: (2017)

ORP5 regulates PI(4)P on the lipid droplet: Novel players on the monolayer
por: Renne, Mike F., et al.
Publicado: (2019)

Identification of novel lipid droplet factors that regulate lipophagy and cholesterol efflux in macrophage foam cells
por: Robichaud, Sabrina, et al.
Publicado: (2021)

Lipophagy: Connecting Autophagy and Lipid Metabolism
por: Singh, Rajat, et al.
Publicado: (2012)

Lipolysis and lipophagy in lipid storage myopathies
por: Angelini, Corrado, et al.
Publicado: (2016)

Dysregulated lipolysis and lipophagy in lipid droplets of macrophages from high fat diet‐fed obese mice
por: Getiye, Yohannes, et al.
Publicado: (2022)

Neuroprotective and Anti-Inflammatory Effects of Linoleic Acid in Models of Parkinson’s Disease: The Implication of Lipid Droplets and Lipophagy
por: Alarcon-Gil, Jesus, et al.
Publicado: (2022)

Komagataella phaffii Cue5 Piggybacks on Lipid Droplets for Its Vacuolar Degradation during Stationary Phase Lipophagy
por: Kumar, Ravinder, et al.
Publicado: (2022)

Involvement of Lipophagy and Chaperone-Mediated Autophagy in the Pathogenesis of Non-Alcoholic Fatty Liver Disease by Regulation of Lipid Droplets
por: Mastoridou, Eleftheria M., et al.
Publicado: (2023)

Alterations of Lipid Profile in Livers with Impaired Lipophagy
por: Jonas, Wenke, et al.
Publicado: (2022)

Lipophagy and Lipolysis Status in Lipid Storage and Lipid Metabolism Diseases
por: Kloska, Anna, et al.
Publicado: (2020)

Thank ORP9 for FFAT: With endosomal ORP10, it’s fission accomplished!
por: Wong, Louise H., et al.
Publicado: (2021)

Regulation of lipid droplet turnover by ubiquitin ligases
por: Alberts, Philipp, et al.
Publicado: (2010)

Impaired lipophagy induced-microglial lipid droplets accumulation contributes to the buildup of TREM1 in diabetes-associated cognitive impairment
por: Li, Qing, et al.
Publicado: (2023)

Adenovirus RIDα uncovers a novel pathway requiring ORP1L for lipid droplet formation independent of NPC1
por: Cianciola, Nicholas L., et al.
Publicado: (2013)

Omega 3-DHA and Delta-Tocotrienol Modulate Lipid Droplet Biogenesis and Lipophagy in Breast Cancer Cells: The Impact in Cancer Aggressiveness
por: Pizato, Nathalia, et al.
Publicado: (2019)

Molecular Machinery of Lipid Droplet Degradation and Turnover in Plants
por: Qin, Zhaoxia, et al.
Publicado: (2023)

Crystal Structure of the ORP8 Lipid Transport ORD Domain: Model of Lipid Transport
por: Eisenreichova, Andrea, et al.
Publicado: (2023)

ORP5 and ORP8: Sterol Sensors and Phospholipid Transfer Proteins at Membrane Contact Sites?
por: Santos, Nina Criado, et al.
Publicado: (2020)

Inhibited Lipophagy Suppresses Lipid Metabolism in Zebrafish Liver Cells
por: Wang, Jing, et al.
Publicado: (2019)

Inhibition of HCV Replication by Oxysterol-Binding Protein-Related Protein 4 (ORP4) through Interaction with HCV NS5B and Alteration of Lipid Droplet Formation
por: Park, In-Woo, et al.
Publicado: (2013)

Liver lipophagy ameliorates nonalcoholic steatohepatitis through extracellular lipid secretion
por: Minami, Yoshito, et al.
Publicado: (2023)

Lipophagy deficiency exacerbates ectopic lipid accumulation and tubular cells injury in diabetic nephropathy
por: Han, Yachun, et al.
Publicado: (2021)

Reconstitution of ORP-mediated lipid exchange process coupled to PI(4)P metabolism
por: Fuggetta, Nicolas, et al.
Publicado: (2023)

Hypothalamic lipophagy and energetic balance
por: Singh, Rajat
Publicado: (2011)

A role for lipophagy in atherosclerosis
por: Laval, Thomas, et al.
Publicado: (2023)

Lipid Droplets and Their Autophagic Turnover via the Raft-Like Vacuolar Microdomains
por: Rahman, Muhammad Arifur, et al.
Publicado: (2021)

Orthogonal targeting of SAC1 to mitochondria implicates ORP2 as a major player in PM PI4P turnover
por: Doyle, Colleen P., et al.
Publicado: (2023)

Reversal of intramyocellular lipid accumulation by lipophagy and a p62-mediated pathway
por: Lam, T, et al.
Publicado: (2016)

Plin2-deficiency reduces lipophagy and results in increased lipid accumulation in the heart
por: Mardani, Ismena, et al.
Publicado: (2019)

Immunity-related GTPase induces lipophagy to prevent excess hepatic lipid accumulation
por: Schwerbel, Kristin, et al.
Publicado: (2020)

XopZ and ORP1C cooperate to regulate the virulence of Xanthomonas oryzae pv. oryzae on Nipponbare
por: Ji, Hongtao, et al.
Publicado: (2022)

ORP5 and ORP8 bind phosphatidylinositol-4, 5-biphosphate (PtdIns(4,5)P(2)) and regulate its level at the plasma membrane
por: Ghai, Rajesh, et al.
Publicado: (2017)

Arabidopsis ORP2A mediates ER–autophagosomal membrane contact sites and regulates PI3P in plant autophagy
por: Ye, Hao, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_na3g0hbppq0d1hlo1ptfhbhj0f