Ehrlichia Wnt SLiM ligand mimic deactivates the Hippo pathway to engage the anti-apoptotic Yap-GLUT1-BCL-xL axis

Ehrlichia chaffeensis TRP120 effector has evolved short linear motif (SLiM) ligand mimicry to repurpose multiple evolutionarily conserved cellular signaling pathways, including Wnt, Notch, and Hedgehog. In this investigation, we demonstrate that E. chaffeensis and recombinant TRP120 deactivate Hippo...

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Detalles Bibliográficos
Autores principales: Byerly, Caitlan D., Patterson, LaNisha L., Pittner, Nicholas A., Solomon, Regina N., Patel, Jignesh G., Rogan, Madison R., McBride, Jere W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10501218/
https://www.ncbi.nlm.nih.gov/pubmed/37530530
http://dx.doi.org/10.1128/iai.00085-23

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10501218/
https://www.ncbi.nlm.nih.gov/pubmed/37530530
http://dx.doi.org/10.1128/iai.00085-23

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