Effect of apatinib on the pharmacokinetics of tramadol and O-desmethyltramadol in rats

Since the combination of anticancer drugs and opioids is very common, apatinib and tramadol are likely to be used in combination clinically. This study evaluated the effects of apatinib on the pharmacokinetics of tramadol and its main metabolite O-desmethyltramadol in Sprague-Dawley (SD) rats and th...

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Detalles Bibliográficos
Autores principales: Bao, Su-su, Tang, Peng-fei, Gao, Nan-yong, Xiao, Zhong-xiang, Qian, Jian-chang, Zheng, Long, Hu, Guo-xin, Xu, Huan-hai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2023
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10501372/
https://www.ncbi.nlm.nih.gov/pubmed/37719112
http://dx.doi.org/10.7717/peerj.16051

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10501372/
https://www.ncbi.nlm.nih.gov/pubmed/37719112
http://dx.doi.org/10.7717/peerj.16051

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