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Effects of six pyrimidine analogs on the growth of Tetrahymena thermophila and their implications in pyrimidine metabolism

Tetrahymena are ciliated protists that have been used to study the effects of toxic chemicals, including anticancer drugs. In this study, we tested the inhibitory effects of six pyrimidine analogs (5-fluorouracil, floxuridine, 5’-deoxy-5-fluorouridine, 5-fluorouridine, gemcitabine, and cytarabine) o...

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Detalles Bibliográficos
Autores principales: Harpel, Zander, Chang, Wei-Jen, Circelli, Jacob, Chen, Richard, Chang, Ian, Rivera, Jason, Wu, Stephanie, Wei, RongHan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10501602/
https://www.ncbi.nlm.nih.gov/pubmed/37708236
http://dx.doi.org/10.1371/journal.pone.0284309