LGP2 directly interacts with flavivirus NS5 RNA-dependent RNA polymerase and downregulates its pre-elongation activities

LGP2 is a RIG-I-like receptor (RLR) known to bind and recognize the intermediate double-stranded RNA (dsRNA) during virus infection and to induce type-I interferon (IFN)-related antiviral innate immune responses. Here, we find that LGP2 inhibits Zika virus (ZIKV) and tick-borne encephalitis virus (T...

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Detalles Bibliográficos
Autores principales: Tan, Zhongyuan, Wu, Jiqin, Huang, Li, Wang, Ting, Zheng, Zhenhua, Zhang, Jianhui, Ke, Xianliang, Zhang, Yuan, Liu, Yan, Wang, Hanzhong, Tao, Jianping, Gong, Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10501626/
https://www.ncbi.nlm.nih.gov/pubmed/37656756
http://dx.doi.org/10.1371/journal.ppat.1011620

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10501626/
https://www.ncbi.nlm.nih.gov/pubmed/37656756
http://dx.doi.org/10.1371/journal.ppat.1011620

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