Discovery of novel aporphine alkaloid derivative as potent TLR2 antagonist reversing macrophage polarization and neutrophil infiltration against acute inflammation

Toll-like receptor 2 (TLR2) mediated macrophages regulate the protective immune response to infectious microorganisms, but the aberrant activation of macrophages often leads to pathological inflammation, including tissue damage. In this study, we identified antagonists of TLR2 by screening 2100 natu...

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Detalles Bibliográficos
Autores principales: Yang, Junjie, Pan, Yue, Zeng, Xiaoshan, Liu, Shuwen, Chen, Zhipeng, Cheng, Kui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10501872/
https://www.ncbi.nlm.nih.gov/pubmed/37719381
http://dx.doi.org/10.1016/j.apsb.2023.05.034

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10501872/
https://www.ncbi.nlm.nih.gov/pubmed/37719381
http://dx.doi.org/10.1016/j.apsb.2023.05.034

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