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How Pol α-primase is targeted to replisomes to prime eukaryotic DNA replication

During eukaryotic DNA replication, Pol α-primase generates primers at replication origins to start leading-strand synthesis and every few hundred nucleotides during discontinuous lagging-strand replication. How Pol α-primase is targeted to replication forks to prime DNA synthesis is not fully unders...

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Detalles Bibliográficos
Autores principales: Jones, Morgan L., Aria, Valentina, Baris, Yasemin, Yeeles, Joseph T.P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10501992/
https://www.ncbi.nlm.nih.gov/pubmed/37506699
http://dx.doi.org/10.1016/j.molcel.2023.06.035