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Mechanism of orphan subunit recognition during assembly quality control

Cells contain numerous abundant molecular machines assembled from multiple subunits. Imbalances in subunit production and failed assembly generate orphan subunits that are eliminated by poorly defined pathways. Here, we determined how orphan subunits of the cytosolic chaperonin CCT are recognized. S...

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Detalles Bibliográficos
Autores principales: Yagita, Yuichi, Zavodszky, Eszter, Peak-Chew, Sew-Yeu, Hegde, Ramanujan S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10501995/
https://www.ncbi.nlm.nih.gov/pubmed/37480851
http://dx.doi.org/10.1016/j.cell.2023.06.016